Research Institute for Industry

nCATS research group


To assess the mechanical performance of a novel design for a Total Knee Joint Replacement system (TKR), compare it to clinically proven designs and prepare a technical report used for submission as part of the European biomedical regulatory process.


  • RIfI was commissioned to conduct a large series of Finite Element Analyses (FEA) of complete TKR systems in order to assess the mechanical performance of different designs and identify the best performing system.
  • The goal was to simulate real physiological conditions.
  • The aim was to provide  an advanced technical report to support our client’s EU regulatory submission process.

What we did

  • Developed a novel methodology combining  Computed Tomography Imaging, Computer Aided Design, FEA and Rigid Body Dynamics simulations.
  • Integrated complex technologies and diverse software environments.
  • Worked closely with the design team and the client’s partners based overseas.


  • Qualitative and quantitative demonstration of the superior performance of the new TKR design over existing ones.
  • Saved time and money to our client by providing a wide range of established expertise, access to state-of-the-art software applications, biomechanical models and large-scale computing clusters.
  • The findings of the RIfI study aided our client in achieving a regulatory CE marking.
Pre-Clinical Computer Modelling of a Total Knee Joint Replacement

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